Sermorelin is a synthetic peptide analog of growth hormone–releasing hormone (GHRH), the naturally occurring peptide produced by the hypothalamus. This article provides an educational overview of how Sermorelin and Glycine work, what is and is not established by clinical evidence, and what patients should discuss with a provider before starting therapy.
Sermorelin acts on GHRH receptors in the pituitary gland, stimulating it to produce and release endogenous growth hormone. Because the pituitary’s natural feedback mechanisms remain active, this differs from direct administration of synthetic exogenous HGH. Growth hormone in healthy adults follows a pulsatile secretion pattern — Sermorelin is understood to act within this hormonal axis rather than bypassing it entirely.
Compounded Sermorelin is not FDA-approved for safety, effectiveness, or quality. Sermorelin acetate (as Geref) was previously FDA-approved for pediatric growth hormone deficiency diagnosis but has since been withdrawn from the U.S. market. Compounded Sermorelin/Glycine is a separate product and not equivalent to any previously FDA-approved formulation.
Glycine is a non-essential amino acid with studied roles in collagen synthesis, neurotransmitter activity (as an inhibitory signaling molecule), and antioxidant production. Regen Doctors combines Glycine with Sermorelin in a compounded formulation. The rationale is based on the independently known biology of each compound. There are no specific clinical trials on this combined compounded formulation. Claims about this combination should be understood in this context.
Patients should distinguish between what is pharmacologically understood and what is directly supported by clinical trial data for this specific product:
The Regen Doctors Sermorelin/Glycine product is offered as a 2000mcg/5mg per mL, 4mL vial at $300 per month, including a kit with syringes, alcohol swabs, and instructions. It is administered by subcutaneous injection, typically in the evening. Protocol details are determined by the prescribing provider. A telemedicine consultation is required before any prescription is issued.
*Educational Content Notice: This article is for informational purposes only and does not constitute medical advice. Compounded Sermorelin/Glycine is not FDA-approved. A valid prescription requires a licensed provider consultation. Individual responses vary and no specific outcome is guaranteed.
*Important Disclosures: Compounded Sermorelin/Glycine is not FDA-approved for safety, effectiveness, or quality. FDA does not approve nor review compounded products. Individual responses vary and no specific outcome is guaranteed. A valid prescription is required following a licensed provider consultation. Available to patients in the lower 48 states (excluding HI & AK). This content does not constitute medical advice.
