NAD+: What It Is and Why Researchers Are Studying It

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell and has become an active area of scientific research — particularly in aging biology. This article offers a factual, educational overview of NAD+ and what is — and is not — currently supported by clinical evidence.

What Is NAD+?

NAD+ is a coenzyme involved in core metabolic processes including the conversion of nutrients into cellular energy (ATP) through the mitochondrial electron transport chain. It also serves as a substrate for enzymes involved in DNA repair signaling and protein regulation. NAD+ is present in all human cells and is derived from vitamin B3 (niacin).

The State of the Research

Research into NAD+ supplementation has grown substantially over the past decade. It is important for patients to understand what this research does and does not show:

• Preclinical evidence: Many findings about NAD+ supplementation come from studies in animal models. While these studies have informed research directions, animal model results do not directly translate to human outcomes.
• Human studies: Some small human trials have examined NAD+ precursor supplementation (such as NMN and NR) and certain biological markers. These studies are generally limited in size and scope, and no broad clinical conclusions have been established.
• No approved medical use: NAD+ supplementation is not FDA-approved to treat, cure, or prevent any disease. Claims about NAD+ should be evaluated in light of available evidence, which is still developing.

Why Delivery Method Is Relevant

NAD+ is rapidly broken down in the digestive tract, which limits oral bioavailability. Alternative delivery routes — such as intranasal or injectable formats — are used to support absorption through mucosal or direct routes. These delivery differences are relevant to how NAD+ is offered clinically, though they do not change the fact that these are compounded, non-FDA-approved products.

Available Formats at Regen Doctors

• NAD+ Nasal Spray: $135 for a 15ml bottle. A compounded intranasal formulation. Not FDA-approved.
• NAD+ Injectable: Subcutaneous format for patients who prefer injectable delivery. Requires a prescription following provider consultation. Not FDA-approved as a compounded product.

The Consultation Process

Whether NAD+ supplementation is appropriate for any individual is a clinical question that a licensed provider evaluates during a telemedicine consultation. A consultation is included with prescription products and is required before any prescription is issued.

*Educational Content Notice: This article is for informational purposes only and does not constitute medical advice. Compounded NAD+ products are not FDA-approved. NAD+ supplementation is not intended to diagnose, treat, cure, or prevent any disease. Individual responses vary. A prescription is required for prescription products.

*Important Disclosures: Compounded NAD+ products are not FDA-approved. These products are not intended to diagnose, treat, cure, or prevent any disease. Individual responses vary and no specific outcome is guaranteed. A licensed provider consultation and valid prescription are required for prescription products. This content does not constitute medical advice.