PT-141 is a peptide used to treat low sexual desire and arousal. Unlike other medications in its category that affect blood flow, PT-141 works on the brain to increase one’s libido. It’s FDA-approved for premenopausal women with hypoactive sexual desire disorder (HSDD) and is also used off-label for men with erectile dysfunction (ED) or low libido.
It’s ideal for individuals who struggle with sexual desire that isn’t caused by stress, relationship issues, or other medical conditions. PT-141 should not be used by those with uncontrolled high blood pressure or cardiovascular disease. It requires a prescription and should be used under a doctor’s supervision.
If low libido is getting in the way, PT-141 can help you get your sex drive back. Talk to a provider at Regen Doctors today.
PT-141, or bremelanotide, is a synthetic peptide that aids to improve sexual desire. It was originally developed to treat skin pigmentation issues, but was later found to have a strong effect on sexual arousal.
It’s usually taken as a subcutaneous injection about 45 minutes before sexual activity. It’s available by prescription only and should be used under the guidance of a licensed provider.
PT-141 works by activating melanocortin receptors in the brain, specifically MC4R, which are linked to sexual desire and arousal. By stimulating these receptors, PT-141 enhances the brain’s signaling for sexual interest, increasing libido and the natural sexual response.
This is different from drugs like Viagra, Cialis, or Levitra that are PDE5 inhibitors which improve blood flow to the genitals. They help with the physical mechanics of an erection, but don’t impact desire or mental arousal. That means they only work if sexual stimulation is already present.
PT-141 targets the central nervous system, not the vascular system. It can increase sexual desire even when psychological factors, like stress or low mood, are involved. That’s why it’s used in both women with hypoactive sexual desire disorder and men with low libido or ED that isn’t purely physical.
PT-141 is FDA-approved to treat low sexual desire in premenopausal women diagnosed with HSDD. It helps restore desire by activating brain pathways that control sexual arousal, without affecting hormone levels or relying on blood flow like other treatments.
Key benefits for women:
Women who don’t respond well to Addyi or other options may find PT-141 more effective, especially if the root issue is neurologic rather than hormonal.
PT-141 is used off-label to help men with low libido or erectile dysfunction, especially when traditional ED meds don’t work. Unlike Viagra or Cialis, PT-141 targets the brain, not just blood flow, making it useful for men with both physical and psychological causes of low sexual function.
Key benefits for men:
PT-141 is especially helpful for men whose sexual dysfunction is related to stress, fatigue, or low sexual desire, not just circulation issues.
You can take PT-141 either as a subcutaneous injection or as a nasal spray. The injection is FDA-approved and provides the most reliable results. The nasal spray is a compounded, off-label option some providers offer for convenience.
Only take PT-141 when needed. It’s not meant for daily use. Wait at least 24 hours between doses. Do not exceed 8 doses per month.
Using it more often doesn’t improve results and may increase the risk of side effects like nausea or high blood pressure. Always follow your provider’s instructions. If you feel like you need to use it more often, talk to your doctor to reassess your treatment plan.
Yes, PT-141 is generally safe when prescribed and used as directed. The FDA approved it in 2019 for treating low sexual desire in premenopausal women. It’s also used off-label for men under medical supervision.
Most users tolerate PT-141 well, but like any medication, it can cause side effects. The most common include:
Less common but more serious side effects may include increased blood pressure. If you have uncontrolled hypertension or cardiovascular issues, your doctor may recommend avoiding it.
To stay safe, don’t exceed the recommended dose and only use PT-141 under the guidance of a licensed medical provider. Also, avoid mixing PT-141 with alcohol or recreational drugs.
Desire isn’t optional. PT-141 helps bring it back. Discreet, doctor-prescribed, and available at Regen Doctors. We serve patients in the Pennsylvania areas, all across Lehigh Valley, including Allentown, Bethlehem, Center Valley, Lansdale, Easton, Pottstown, and surrounding New Jersey areas.
