Taking clomiphene encourages your brain to release two hormones: LH (luteinizing hormone) and FSH (follicle-stimulating hormone). These hormones tell the testicles when to ramp up testosterone production (Mbi Feh, 2022). Because Clomid doesn’t dull testosterone production like TRT, it maintains male fertility.

What Is Clomid?

Clomid is a medication approved for the treatment of hormonal imbalance fertility issues in women, specifically anovulatory and oligo-ovulatory infertility issues in women. These may be caused by a variety of factors, either as a result of polycystic ovarian syndrome or as a result of birth control use.

These are very specific kinds of infertility — in both cases, the cause of infertility is a lack of normal ovulation. In both cases, Clomid induces ovulation.

The Food and Drug Administration (FDA) has approved Clomid (specifically its generic version, clomiphene) for both of these kinds of infertility, but when it comes to men, there’s less clarity.

Currently, clomiphene is prescribed off-label to treat infertility in men. That is, healthcare professionals prescribe this medication for male infertility even though it’s not approved for that use by the FDA.

It can also be used as a treatment for hypogonadism or low serum testosterone levels in certain men. This has occasionally been abused in healthy athletes as a performance enhancer to increase muscle mass through the effects of testosterone — but we’re here to talk about fertility, so let’s focus on that.

How to use Clomiphene Citrate

Clomiphene must be taken by mouth exactly as directed by your doctor in order to be most effective. It is important to follow your dosing schedule carefully.

Your dosage is based on your medical condition and response to therapy. Do not take it more often or for a longer time than prescribed by your doctor. Long-term treatment with this medication is not recommended and should not be more than 6 cycles.

You may be directed to record your body temperature, perform ovulation tests, and properly time sexual intercourse for best results. Ask your doctor if you have any questions.

Proper Use

Take this medicine only as directed by your doctor. If you are to begin on Day 5, count the first day of your menstrual period as Day 1. Beginning on Day 5, take the correct dose every day for as many days as your doctor ordered. To help you to remember to take your dose of medicine, take it at the same time every day.


The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
  • For treating infertility: Adults—50 milligrams (mg) a day for five days of a menstrual cycle. The treatment is usually started on the fifth day of your menstrual period. If you do not have menstrual cycles, you can begin taking your medicine at any time. If you do not become pregnant after the first course, your doctor may increase your dose a little at a time up to 250 mg a day. Your treatment may be repeated until you do become pregnant or for up to four treatment cycles.